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Single-Use Pre-Filled Spray Device

The NICE Single-Use Pre-Filled Spray Device is a pharmaceutical packaging material capable of long-term, effective drug storage with excellent stability and compatibility. During use, the nebulizer converts the liquid medication into fine, uniformly-sized mist particles, which are sprayed onto the patient's mucous membranes (such as nasal or oral mucosa) to achieve drug delivery. This product allows the drug solution to be pre-filled into a glass tube and sealed for storage, facilitating transportation. Consequently, it eliminates the need for transferring the drug solution into a syringe during application, reducing staff workload; it prevents drug loss and waste caused by residual solution in the device; and it minimizes the risk of contamination to either the drug solution or the device during transfer, thereby avoiding potential safety and hygiene issues.

Description

Product Advantages
• Material Stability
The device utilizes high-quality borosilicate glass, which offers excellent chemical stability and impact resistance, widely used for containing biological agents, vaccines, and other pharmaceutical preparations.
• Superior Seal
Equipped with a protective cap on the spray nozzle and an internal sealing structure, the device achieves complete bacterial isolation, ensuring no leakage during transportation and handling.
• Effective Nebulization
The precision turbo-designed nebulization chamber ensures effective atomization of the drug solution, producing fine mist particles with even spray coverage, allowing direct application to human mucous membranes.
• Accurate Dosage
A precise dosage limit mechanism guarantees consistent dosage per administration.
• Single-Use Design
The device features a self-destruct function. After use, the rubber stopper remains locked inside the glass tube and cannot be removed, preventing reuse.
Therapeutic Advantages of Nasal Administration
Nasal drug delivery via mucosal absorption is an effective therapeutic approach. The nasal mucosa is smooth, moist, and richly vascularized. Locally, nasal drops or sprays can achieve effects such as anti-inflammatory, antibacterial, decongestant, and hemostatic treatments. Systemically, nasal administration can also produce whole-body effects; for example, metamizole nasal drops have antipyretic properties.
Compared to administration routes like intravenous injection, nasal delivery offers several advantages: for instance, the activity of hydrolytic enzymes in the nasal mucosa is lower than in the gastrointestinal tract, reducing the degradation of macromolecular compounds such as polypeptides, hormones, and vaccines, thereby ensuring drug delivery quality. It avoids hepatic first-pass effects associated with oral medications and potential liver damage from drugs, resulting in high bioavailability. It enables brain-targeted delivery, is convenient to use, has minor adverse reactions, offers good compliance, and is particularly suitable for infants and children.
In recent years, due to its unique advantages, nasal spray vaccines have emerged as a new direction in research and application. Studies have shown that nasal mucosal immunization can induce not only local mucosal immune responses but also systemic immune responses. Its immunogenic effect is comparable to subcutaneous injection and can be even more effective and potent than oral immunization. Nasal spray vaccines further expand the applications of nasal drug delivery.